Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture.
Identifieur interne : 000161 ( Main/Exploration ); précédent : 000160; suivant : 000162Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture.
Auteurs : Tatiane M. Vicentini [Brésil] ; Amanda H. Cavalheiro [Brésil] ; Carlos R P. Dechandt [Brésil] ; Luciane C. Alberici [Brésil] ; Carem G. Vargas-Rechia [Brésil]Source :
- Plant physiology and biochemistry : PPB [ 1873-2690 ] ; 2019.
Descripteurs français
- KwdFr :
- Aluminium (pharmacologie), Consommation d'oxygène (effets des médicaments et des substances chimiques), Jatropha (effets des médicaments et des substances chimiques), Jatropha (enzymologie), Jatropha (métabolisme), Mitochondries (effets des médicaments et des substances chimiques), Mitochondries (métabolisme), Oxidoreductases (antagonistes et inhibiteurs), Oxidoreductases (métabolisme), Oxydoréduction (effets des médicaments et des substances chimiques), Protéines mitochondriales (antagonistes et inhibiteurs), Protéines mitochondriales (métabolisme), Protéines végétales (antagonistes et inhibiteurs), Protéines végétales (métabolisme), Techniques de culture cellulaire (MeSH).
- MESH :
- antagonistes et inhibiteurs : Oxidoreductases, Protéines mitochondriales, Protéines végétales.
- effets des médicaments et des substances chimiques : Consommation d'oxygène, Jatropha, Mitochondries, Oxydoréduction.
- enzymologie : Jatropha.
- métabolisme : Jatropha, Mitochondries, Oxidoreductases, Protéines mitochondriales, Protéines végétales.
- pharmacologie : Aluminium.
- Techniques de culture cellulaire.
English descriptors
- KwdEn :
- Aluminum (pharmacology), Cell Culture Techniques (MeSH), Jatropha (drug effects), Jatropha (enzymology), Jatropha (metabolism), Mitochondria (drug effects), Mitochondria (metabolism), Mitochondrial Proteins (antagonists & inhibitors), Mitochondrial Proteins (metabolism), Oxidation-Reduction (drug effects), Oxidoreductases (antagonists & inhibitors), Oxidoreductases (metabolism), Oxygen Consumption (drug effects), Plant Proteins (antagonists & inhibitors), Plant Proteins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Mitochondrial Proteins, Oxidoreductases, Plant Proteins.
- chemical , metabolism : Mitochondrial Proteins, Oxidoreductases, Plant Proteins.
- chemical , pharmacology : Aluminum.
- drug effects : Jatropha, Mitochondria, Oxidation-Reduction, Oxygen Consumption.
- enzymology : Jatropha.
- metabolism : Jatropha, Mitochondria.
- Cell Culture Techniques.
Abstract
Aluminum (Al) toxicity has been recognized to be a main limiting factor of crop productivity in acid soil. Al interacts with cell walls disrupting the functions of the plasma membrane and is associated with oxidative damage and mitochondrial dysfunction. Jatropha curcas L. (J. curcas) is a drought resistant plant, widely distributed around the world, with great economic and medicinal importance. Here we investigated the effects of Al on J. curcas mitochondrial function and cell viability, analyzing mitochondrial respiration, phenolic compounds, reducing sugars and cell viability in cultured J. curcas cells. The results showed that at 70 μM, Al limited mitochondrial respiration by inhibiting the alternative oxidase (AOX) pathway in the respiratory chain. An increased concentration of reducing sugars and reduced concentration of intracellular phenolic compounds was observed during respiratory inhibition. After inhibition, a time-dependent upregulation of AOX mRNA was observed followed by restoration of respiratory activity and reducing sugar concentrations. Cultured J. curcas cells were very resistant to Al-induced cell death. In addition, at 70 μM, Al also appeared as an inhibitor of cell wall invertase. In conclusion, Al tolerance in cultured J. curcas cells involves a inhibition of mitochondrial AOX pathway, which seems to start an oxidative burst to induce AOX upregulation, which in turn restores consumption of O2 and substrates. These data provide new insight into the signaling cascades that modulate the Al tolerance mechanism.
DOI: 10.1016/j.plaphy.2019.01.012
PubMed: 30660100
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Café s/n, 14040-903, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Plant physiology and biochemistry : PPB</title><idno type="eISSN">1873-2690</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aluminum (pharmacology)</term><term>Cell Culture Techniques (MeSH)</term><term>Jatropha (drug effects)</term><term>Jatropha (enzymology)</term><term>Jatropha (metabolism)</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Mitochondrial Proteins (antagonists & inhibitors)</term><term>Mitochondrial Proteins (metabolism)</term><term>Oxidation-Reduction (drug effects)</term><term>Oxidoreductases (antagonists & inhibitors)</term><term>Oxidoreductases (metabolism)</term><term>Oxygen Consumption (drug effects)</term><term>Plant Proteins (antagonists & inhibitors)</term><term>Plant Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aluminium (pharmacologie)</term><term>Consommation d'oxygène (effets des médicaments et des substances chimiques)</term><term>Jatropha (effets des médicaments et des substances chimiques)</term><term>Jatropha (enzymologie)</term><term>Jatropha (métabolisme)</term><term>Mitochondries (effets des médicaments et des substances chimiques)</term><term>Mitochondries (métabolisme)</term><term>Oxidoreductases (antagonistes et inhibiteurs)</term><term>Oxidoreductases (métabolisme)</term><term>Oxydoréduction (effets des médicaments et des substances chimiques)</term><term>Protéines mitochondriales (antagonistes et inhibiteurs)</term><term>Protéines mitochondriales (métabolisme)</term><term>Protéines végétales (antagonistes et inhibiteurs)</term><term>Protéines végétales (métabolisme)</term><term>Techniques de culture cellulaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Mitochondrial Proteins</term><term>Oxidoreductases</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mitochondrial Proteins</term><term>Oxidoreductases</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aluminum</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Oxidoreductases</term><term>Protéines mitochondriales</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Jatropha</term><term>Mitochondria</term><term>Oxidation-Reduction</term><term>Oxygen Consumption</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Consommation d'oxygène</term><term>Jatropha</term><term>Mitochondries</term><term>Oxydoréduction</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Jatropha</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Jatropha</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Jatropha</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Jatropha</term><term>Mitochondries</term><term>Oxidoreductases</term><term>Protéines mitochondriales</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aluminium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Culture Techniques</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Techniques de culture cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aluminum (Al) toxicity has been recognized to be a main limiting factor of crop productivity in acid soil. Al interacts with cell walls disrupting the functions of the plasma membrane and is associated with oxidative damage and mitochondrial dysfunction. Jatropha curcas L. (J. curcas) is a drought resistant plant, widely distributed around the world, with great economic and medicinal importance. Here we investigated the effects of Al on J. curcas mitochondrial function and cell viability, analyzing mitochondrial respiration, phenolic compounds, reducing sugars and cell viability in cultured J. curcas cells. The results showed that at 70 μM, Al limited mitochondrial respiration by inhibiting the alternative oxidase (AOX) pathway in the respiratory chain. An increased concentration of reducing sugars and reduced concentration of intracellular phenolic compounds was observed during respiratory inhibition. After inhibition, a time-dependent upregulation of AOX mRNA was observed followed by restoration of respiratory activity and reducing sugar concentrations. Cultured J. curcas cells were very resistant to Al-induced cell death. In addition, at 70 μM, Al also appeared as an inhibitor of cell wall invertase. In conclusion, Al tolerance in cultured J. curcas cells involves a inhibition of mitochondrial AOX pathway, which seems to start an oxidative burst to induce AOX upregulation, which in turn restores consumption of O<sub>2</sub> and substrates. These data provide new insight into the signaling cascades that modulate the Al tolerance mechanism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30660100</PMID><DateCompleted><Year>2019</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2690</ISSN><JournalIssue CitedMedium="Internet"><Volume>136</Volume><PubDate><Year>2019</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Plant physiology and biochemistry : PPB</Title><ISOAbbreviation>Plant Physiol Biochem</ISOAbbreviation></Journal><ArticleTitle>Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture.</ArticleTitle><Pagination><MedlinePgn>92-97</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0981-9428(19)30020-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.plaphy.2019.01.012</ELocationID><Abstract><AbstractText>Aluminum (Al) toxicity has been recognized to be a main limiting factor of crop productivity in acid soil. Al interacts with cell walls disrupting the functions of the plasma membrane and is associated with oxidative damage and mitochondrial dysfunction. Jatropha curcas L. (J. curcas) is a drought resistant plant, widely distributed around the world, with great economic and medicinal importance. Here we investigated the effects of Al on J. curcas mitochondrial function and cell viability, analyzing mitochondrial respiration, phenolic compounds, reducing sugars and cell viability in cultured J. curcas cells. The results showed that at 70 μM, Al limited mitochondrial respiration by inhibiting the alternative oxidase (AOX) pathway in the respiratory chain. An increased concentration of reducing sugars and reduced concentration of intracellular phenolic compounds was observed during respiratory inhibition. After inhibition, a time-dependent upregulation of AOX mRNA was observed followed by restoration of respiratory activity and reducing sugar concentrations. Cultured J. curcas cells were very resistant to Al-induced cell death. In addition, at 70 μM, Al also appeared as an inhibitor of cell wall invertase. In conclusion, Al tolerance in cultured J. curcas cells involves a inhibition of mitochondrial AOX pathway, which seems to start an oxidative burst to induce AOX upregulation, which in turn restores consumption of O<sub>2</sub> and substrates. These data provide new insight into the signaling cascades that modulate the Al tolerance mechanism.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vicentini</LastName><ForeName>Tatiane M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Av. Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavalheiro</LastName><ForeName>Amanda H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Av. Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dechandt</LastName><ForeName>Carlos R P</ForeName><Initials>CRP</Initials><AffiliationInfo><Affiliation>Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Av. Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alberici</LastName><ForeName>Luciane C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Av. Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vargas-Rechia</LastName><ForeName>Carem G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Av. Café s/n, 14040-903, Ribeirão Preto, SP, Brazil. Electronic address: cvrechia@fcfrp.usp.br.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Plant Physiol Biochem</MedlineTA><NlmUniqueID>9882449</NlmUniqueID><ISSNLinking>0981-9428</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024101">Mitochondrial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>CPD4NFA903</RegistryNumber><NameOfSubstance UI="D000535">Aluminum</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="C088813">alternative oxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000535" MajorTopicYN="N">Aluminum</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018929" MajorTopicYN="N">Cell Culture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031286" MajorTopicYN="N">Jatropha</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024101" MajorTopicYN="N">Mitochondrial Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010088" MajorTopicYN="N">Oxidoreductases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010101" MajorTopicYN="N">Oxygen Consumption</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alternative oxidase</Keyword><Keyword MajorTopicYN="N">Invertase activity</Keyword><Keyword MajorTopicYN="N">Jatropha curcas cell culture</Keyword><Keyword MajorTopicYN="N">Mitochondrial respiration</Keyword><Keyword MajorTopicYN="N">Phenolic compounds</Keyword><Keyword MajorTopicYN="N">Reducing sugars</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>01</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30660100</ArticleId><ArticleId IdType="pii">S0981-9428(19)30020-8</ArticleId><ArticleId IdType="doi">10.1016/j.plaphy.2019.01.012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Vicentini, Tatiane M" sort="Vicentini, Tatiane M" uniqKey="Vicentini T" first="Tatiane M" last="Vicentini">Tatiane M. Vicentini</name></region><name sortKey="Alberici, Luciane C" sort="Alberici, Luciane C" uniqKey="Alberici L" first="Luciane C" last="Alberici">Luciane C. Alberici</name><name sortKey="Cavalheiro, Amanda H" sort="Cavalheiro, Amanda H" uniqKey="Cavalheiro A" first="Amanda H" last="Cavalheiro">Amanda H. Cavalheiro</name><name sortKey="Dechandt, Carlos R P" sort="Dechandt, Carlos R P" uniqKey="Dechandt C" first="Carlos R P" last="Dechandt">Carlos R P. Dechandt</name><name sortKey="Vargas Rechia, Carem G" sort="Vargas Rechia, Carem G" uniqKey="Vargas Rechia C" first="Carem G" last="Vargas-Rechia">Carem G. Vargas-Rechia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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